Solhee Tucker

ML / Bioinformatics Engineer

An engineer who speaks biology.

Grounded in real data, not just plausible output, with a solid software engineering background behind it.

Projects

AI agent · Bioinformatics

Gut Pilot: an AI reviewer for microbiome analysis

An AI agent proposes every analysis decision and backs it with a citation. I review each one, confirm or override it. Fixed demo on two real datasets: colorectal cancer and Parkinson's disease.

  • Python
  • FastAPI
  • Claude
  • React
  • 16S rRNA
View case study
12345678910

Each gate: a cited proposal you confirm or override

10reviewer gates across a 3-layer pipeline
Regulatory genomics · ML

Predicting gene expression from histone marks

Histone marks near a gene's TSS predict how much it's expressed, mostly from one feature. I checked it against four regression models to rule out a modeling artifact.

  • Python
  • scikit-learn
  • gene regulation
  • ChIP-seq
View case study
Held-out genes
8,425
Model
HistGradientBoosting
Coral line
perfect prediction
0.76correlation between predicted and actual expression
Bioinformatics · LLM summaries

Turning an rs ID into a bioinformatics summary

Pulls NCBI and Ensembl data and grounds the summary in real PubMed citations instead of model recall. Fixed demo from a bioinformatics hackathon.

  • NCBI
  • Ensembl
  • PubMed
  • Next.js
View case study
HTR2Ars6311~290 bp upstreamNCBIEnsemblPubMed
149studies linked to rs6311 in dbSNP
Single-cell genomics

Reading COVID-19 in 100,000 blood cells

COVID-19 blood has more activated effector cells and fewer resting naive and memory cells. Built from CELLxGENE Census data into an interactive chart.

  • Python
  • scanpy
  • single-cell RNA-seq
  • Next.js
View case study
fewer in COVID-19more
12.9xmore mature T cell in COVID-19 blood
Contact
Location
San Jose, California, USA